Chronic pancreatitis (CP) is a significant source of morbidity, mortality, and reduced quality of life. A common symptom of CP is severe abdominal pain, and it is associated with adverse effects on physical, psychological, and social functioning. Despite these concerning impacts, pain self-management programs have not yet been developed or evaluated for individuals with CP. Instead, pancreatitis pain is typically managed with opioids which can have limited efficacy and negative side effects. In other chronic pain conditions, cognitive-behavioral therapy (CBT) programs have improved patient outcomes (e.g., pain-related disability, depression) without pharmacological treatment. Therefore, this study aimed to evaluate the feasibility and acceptability of an internet-delivered CBT program for individuals with CP pain, as well as its impact on pain outcomes (pain interference, pain intensity, and quality of life). The study consisted of 30 adult participants with CP. Participants were randomized to either internet-delivered CBT (Pancreatitis Pain Course) or a wait-list control. The Pancreatitis Pain Course delivered 5 lessons over a span of 8 weeks that gave participants information to understand their pain, a range of CBT skills to manage their symptoms, and homework assignments to practice the skills. Pain outcomes were assessed at pre-treatment, post-treatment and 3-month follow-up, and qualitative interviews were conducted at post-treatment. Eighty percent of participants rated the program as highly acceptable and 64.3% completed all 5 lessons. The qualitative interviews showed that participants found the program relevant and helpful, and patients in the treatment group experienced reduced pain intensity and pain interference. Because this is the first trial of a CBT pain self-management intervention for adults with CP pain, future trials are needed to further assess its ability to reduce pain and disability.