Prior research suggests disproportionate endorsement of pain among Black, Indigenous, and People of Color (BIPOC) compared to White people. Considering the high prevalence of pain in persons with MS, the present study examined potential racial-ethnic differences in pain interference among adults with MS, both before and after participation in one of two telehealth interventions aimed at improving pain, fatigue, and depressive symptoms. A national sample of adults with MS and chronic fatigue, chronic pain and/or moderate depressive symptoms (N=163) participated in a randomized controlled trial of self-management intervention focused on cognitive behavioral therapy (n=75) versus MS education (n=88), both delivered 1:1 via telephone. T-tests explored racial-ethnic differences in pain interference at baseline and posttreatment. Hierarchical multiple regression assessed race/ethnicity as a predictor of posttreatment pain interference controlling for baseline pain interference, and in subsequent blocks explored treatment condition, treatment satisfaction variables and baseline perceived social support as factors accounting for potential racial-ethnic differences and variance in pain interference. Independent sample t-tests revealed significant racial-ethnic differences in pain interference at baseline, t(159)=2.30, p=.023 and posttreatment, t(141)=2.91, p=.004. Specifically, participants who identified as (BIPOC) endorsed greater pain interference at baseline (M=4.66, SD=2.54) and posttreatment (M=4.31, SD=2.56) compared to non-Hispanic White participants (M=3.59, SD=2.32 and M=2.81, SD=2.11, respectively). Hierarchical regression analysis revealed a significant relationship between race and posttreatment pain interference, which became non-significant after controlling for baseline pain interference. Perceived social support emerged as significantly associated with posttreatment pain interference, after controlling for all variables. Ethnicity/race and perceived level of social support accounted for more variance in posttreatment pain interference than treatment type. Future investigations aimed at understanding why BIPOC report higher pain levels posttreatment are necessary to inform and adapt current treatments to address more relevant factors contributing to BIPOC’s experience of pain.