There are countless times in the past where people have attempted to expose systematic injustices committed by the U.S. government. Despite the fact that Hanford was a critical site in producing plutonium for the atomic bombs dropped during World War II, the contamination and subsequent health disparities remain shrouded in mystery and present dangers to future generations. In this project, we explore how the Hanford facility and the release of radioactive waste impacted the culture and daily activities related to diet, health, and faith of indigenous peoples in Washington State, as well as efforts by the government and native tribes that have been made in regards to cleaning Hanford and protecting tribal lands. By comparing interviews of Native Americans affected by the Manhattan Project, their oral histories, literature, public speeches, and using website discourse analysis of governmental sites, we made several important observations. Through our research, we found that among the devastating results of the Hanford contamination, the most common theme was the upheaval and marginalization of indigenous culture and the resulting inability of Natives to take part in community building activities such as wild game hunting, fishing, spiritual ceremonies, and trade with neighboring tribes. Not only did contamination tarnish relationships that local natives had with each other and the land, but there was and remains a strong correlation between subsequent cancer-related health disparities and bioaccumulation in natural resources. Nuclear radiation resulting from the Manhattan Project is not an issue of the past; its effects are far-reaching and will continue to mutate the physical and cultural conditions of the Native American tribes who lived in the area, relied on its resources, and were biologically affected by the processes involved at Hanford.