All over the globe, an escalating number of people are developing distressing sensitivities to our environment’s everyday intoxicants. Multiple chemical sensitivity (MCS)—also termed idiopathic environmental intolerances (IEI), among other names—is an acquired disorder characterized by a wide range of symptoms and reactions to low-level chemical exposures. Studies conducted in Japan, USA, Sweden, and Denmark found that 12% of the population has been diagnosed with chemical hypersensitivity, while total underreported prevalence is estimated between 15% and 27%. More importantly, research states that prevalence has increased by 300% within the past decade. People diagnosed with MCS experience a range of symptoms, examples including asthma, heart irregularities, headaches, dizziness, confusion, skin irritation, and fatigue. Abundant in our everyday environment, commonly reported triggers include pesticides, building or renovation materials, car exhaust and chemical smog, smoke, perfumes and fragrances, and cleaning supplies, among others. With a myriad of proposed titles, contrasting research perspectives and approaches, and a staggering dissensus on physiology and diagnosis, it is critical that we compare and contrast the existing literature by geographical region. Three primary research hubs generate the majority of contrasting MCS research; these regions include the United States and Canada, Scandinavia, and Japan. The problematic inconsistencies include (1) a lack of consensus definition or diagnosis for the illness, (2) varying perceptions on pathophysiology, and therefore (3) contrasting treatment strategies. This research aims to examine the global, contrasting research approaches, proposals for treatment or action, and subsequent healthcare experiences within the geographical regions of focus. Preliminary results suggest that inconsistencies in the medical diagnosis of MCS lead to deficiencies in research and ineffective healthcare. By any given title, the escalating number of chemically hypersensitive patients is a growing global health concern. Integrating the globally contrasting approaches and diagnosis criterion is the first step to developing efficient healthcare strategies.