Before the Battle of Lepanto on October 7, 1571, the Republic of Venice’s relations with the Ottoman Empire were tumultuous and tentative. As the most powerful Mediterranean maritime force in the 16th century, it was Venice’s mission to protect Christendom from Ottoman Islamic armies. To fight this maritime crusade Venice employed privateers and corsairs, individuals who, in exchange for payments, supplied their own vessels to police the waters of the Eastern Mediterranean in search of Ottoman vessels. Since Venice relied on trade for basic provisions, Venetian authorities approached naval aggression as a necessary defensive measure. Venice’s lack of self-sustainability meant that protecting its imperial holdings was critical to the longevity of the city itself. As Venice won the Battle of Lepanto, destroying the Ottoman fleet, Venetians regained their sense of naval supremacy. Although Venice lost the larger Ottoman-Venetian war, as in the three previous was, the Battle of Lepanto marked a pivotal moment in Mediterranean history, driving Venetians to recapture some of what they had lost and to rebuild their once vast merchant empire. Confident in their naval prowess, Venice’s merchant galleys spread far and wide across the Eastern Mediterranean to forge new trade relations with the Ottoman Empire. Through these relations, Venice portrayed themselves as the gateway to the East by supplying themselves and Western Europe with exotic goods. I argue that The Battle of Lepanto ushered in a new era of economic expansionism grounded in a Venetian sense of naval superiority that allowed Venice to end its reliance on privateering and corsairing to protect its empire.