Sickle cell disease (SCD) is a genetic blood disorder characterized by recurrent painful episodes. Having frequent pain is a key predictor of morbidity and mortality. Cognitive-behavioral therapy (CBT) interventions for other chronic pain conditions lead to symptom reduction and improved health-related quality of life, and may also be beneficial for adolescents with SCD. However, most adolescents with SCD do not have access to CBT. Internet-based interventions have been used in other populations for providing access to pain self-management strategies. Thus, the primary goal of this pilot study was to determine the feasibility and acceptability of an internet-based CBT program for pain management (Web-MAP), an 8-session program used effectively to reduce pain-related disability in youth with other chronic pain conditions. Twenty-five adolescents, aged 11-18 years (M= 14.76, SD= 2.05), and their parents were randomly assigned to internet CBT (n = 15) or internet pain education (n = 10). They completed assessments at pre-treatment, post-treatment, and six months follow-up. Eight parent-child dyads randomized to CBT also completed qualitative interviews. Results showed that adolescents and parents were highly engaged with Web-MAP, completing an average of 6 out of 8 modules and logging in on average 16.7 and 17.4 times respectively over 8 weeks. 75% of families interviewed would recommend Web-MAP, although they would prefer a program more tailored to youth with SCD. In conclusion, this pilot study suggests that Web-MAP is a feasible and acceptable treatment for adolescents with SCD and their parents, and may be helpful in improving pain-related disability. Future work will focus on specific tailoring of Web-MAP for SCD to better meet the needs of this population.