The Executive Office of the President has declared opioid misuse among youth a national epidemic owing to its prevalence and the severe associated consequences. Little research has been conducted on the types of opioid prescriptions provided to children and their family members, which are the primary source of misused opioids. Knowledge of the trends in opioid prescriptions to children and families could help us better understand the rise in misuse. Therefore, our aim was to uncover trends in the quantity, type and reason for opioid prescriptions as well as sociodemographic factors associated with opioid prescriptions to children and adolescents ages 0-17 and their families from 1996-2012. Secondary data analysis was performed on a population-based sample from the Medical Expenditures Panel Surveys (MEPS). MEPS are a set of surveys that collect data on the healthcare of a nationally representative sample of approximately 40,000 US citizens annually. We abstracted information on demographics, type of opioid prescribed, number of opioid prescriptions per participant, whether a family member received an opioid prescription, and medical diagnoses associated with opioid prescriptions. We found that while the number of opioid prescriptions to the family members of children and adolescents increased by 71% from 1996 to 2012, the portion of children and adolescents prescribed opioids remained stable at around 2.8% annually. Among children and adolescents, those who were white-non-Hispanic, older in age, and had private insurance had higher odds of being prescribed opioids. Furthermore, we found that codeine was the most commonly prescribed opioid in pediatric populations, accounting for 40% of all pediatric opioid prescriptions despite guidance from the U.S. Food & Drug Administration to limit codeine prescriptions in youth. These findings add to our understanding of opioid prescribing trends and will be important for guiding future research and clinical practice to ensure adequate, safe, and effective use of opioids.