Alcohol consumption among college students has long been a serious concern. Previous studies of college students have consistently found an association between heavy alcohol use and academic performance. This study examined the peak past month alcohol use as a function of sex, academic major, and academic performance among college students. 3003 participants completed a paid screening survey as part of a larger study evaluating the efficacy of a web-based intervention for heavy drinking and depressed college students. Measures included birth sex, academic major (STEM versus non-STEM; Science, Technology, Engineering, Mathematics), grade point average (GPA), and the peak number of drinks consumed on one occasion in the previous month. Hierarchical multiple regression analyses evaluated impact of sex, academic major, and GPA on peak alcohol consumption among college students. Significant main effects indicated that males, those with non-STEM majors, and those with lower GPAs drank more than other students. No two-way interactions were found. However, a significant three-way interaction indicated that males who are in STEM majors with high GPAs drank significantly less than those who have lower GPAs, while this relationship is not true for females, or for males who are in non-STEM majors. Implications and limitations of these findings are discussed. Future interventions on alcohol consumption among college students can be targeted to specific groups. Future studies using longitudinal designs to determine causality of the relationship between academic performance (attendance, activity involvement, etc., besides GPA) and alcohol consumption among college students are warranted.