Culture may be an important factor to consider when analyzing men's help-seeking behaviors in response to a prostate cancer diagnosis. In order to explore what role culture might play when men make decisions regarding their prostate cancer, a systematic review of the literature spanning nine research databases took place. Those research databases were: PsychINFO, PubMed, Medscape, Web of Science, Google Scholar, BIOSIS Previews, JSTOR, PsychArticles and ScienceDirect. While many researchers state culture may play a role in defining a man's help-seeking behaviors after prostate cancer has been diagnosed, the literature fails to show, with convincing evidence, information that is necessary to understand this finding. Understanding how men make decisions about their health needs has to be expanded beyond men and women. Therefore, more research must be done that analyzes men's help-seeking behaviors with cancer from a cultural perspective. The lack of information in the literature leaves a potentially integral factor in men's help-seeking behavior out of the realm of consideration, and more research on the subject would be beneficial to the field.