Colonization is often associated with exploitation of local laborers. However, the degree to which physical activity in local populations changes following colonization depends upon the policies of the colonizers, and the technology that is locally available. This research tests the null hypothesis that levels of physical activity, as evidenced by osteoarthritis in human skeletons, remained constant at Epidamnus, Albania during Greek and Roman colonial occupation (620-100BC). To test this hypothesis, 80 skeletons from Epidamnus were examined for evidence of osteoarthritis, and scored according to international standardized protocols. Of these 80 individuals, 27 were adults that showed sufficient preservation for analysis of osteoarthritis. Results indicate that osteoarthritis was more pronounced in all joint surfaces during the Greek than the Roman period (shoulder, elbow, wrist, hip, knee, ankle, cervical vertebra, and temporomandibular joint), with the exception of the thoracic and lumbar vertebrae. Chi-square indicates that this pattern is statistically significant in the shoulder (p=0.02) and ankle (p=0.003), and approaches significance in the elbow (p=0.09), wrist (p=0.06), and temporomandibular joint (p=0.06). These results do not support the null hypothesis of no change from the Greek to the Roman period. Historical documents indicate that Greek colonization resulted in increased dependence on agriculture and largely replaced nomadic pastoralism in local Illyrians. The Romans then introduced new technologies to increase agricultural efficiency. The emerging pattern indicates that the introduction of new, sophisticated technology made life easier for Illyrians during the Roman period. However, the impacts of small sample size are also considered.