This study focuses on how the global efforts of a politically active and increasingly visible movement of adult autistic activists are challenging the common framing of autism and shifting the contemporary autism debate. Common representations throughout the autism field contextualize the autistic experience through diagnostic categories of difference, constructed primarily by psychologists, neurologists, educators, and service providers. These characterizations are determined through observational criteria such as delayed communication, repetitive physical behaviors, and marked deficits in social skills. While the deficit mindset dominates the media and the public perception of autism, there is a lack of attention and research on how the social impact of these ‘perspectives from the outside’ influence the lived experience of autistic adults. This work counters the hegemonic deficit interpretation by investigating the multiple meanings of autism, and studying whether politicized tensions over autistic representations—and misrepresentations— influence public conversations surrounding service delivery, treatment design, and provisions of care. Drawing on qualitative cultural research methods including narrative, textual and image analysis, as well as ethnographic field notes, this study critically analyzes the lived experience of adult autistics and their efforts to re-humanize public assumptions about autism while living in a society, they suggest, that stigmatizes their experience as emotionally isolated, socially deficient, and mentally diseased. I analyze the socio-political discourse of autism and the conflicting representations put forth by medical professionals, mainstream media, institutions, scholars, and—autistics. These contradictory interpretations produce a cultural system of difference engaged in debate over autistic autonomy, self-determination, and justice. To critically engage this ‘culture war’ this inquiry considers who has the right to speak for the autistic community? Whose values are characterized as authentic by the public? Finally, this investigation asks, can autistics redefine autism and how will this definition reframe their position in political discussions about them?